Cannabinoid receptor 2 positions and retains marginal zone B cells within the splenic marginal zone
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چکیده
منابع مشابه
Cannabinoid receptor 2 positions and retains marginal zone B cells within the splenic marginal zone
Specialized B cells residing in the splenic marginal zone (MZ) continuously survey the blood for antigens and are important for immunity to systemic infections. However, the cues that uniquely attract cells to the MZ have not been defined. Previous work demonstrated that mice deficient in cannabinoid receptor 2 (CB2) have decreased numbers of MZ B cells but it has been unclear whether CB2 regul...
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Splenic marginal zone lymphoma (SMZL) is a specific low-grade small B-cell lymphoma that is incorporated in the World Health Organization classification. Characteristic features are splenomegaly, moderate lymphocytosis with villous morphology, intrasinusoidal pattern of involvement of various organs, especially bone marrow, and relative indolent course. Tumor progression with increase of blasti...
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ژورنال
عنوان ژورنال: Journal of Experimental Medicine
سال: 2011
ISSN: 1540-9538,0022-1007
DOI: 10.1084/jem.20111083